Science of epistemology
Science of epistemology is the scientific study of knowledge. Knowledge is information that is useful and in a coherent structure. Knowledge can be both true and false at the same time. The coherent structure of the system of knowledge is what makes sense out of the apparent contradictions.
Experience machines can produce different realities. Different realities can have knowledge about useful behaviors that is different. What is true in one reality may be false in another reality. How do we know if something is true or false thus knowledge or not knowledge in a reality? Something is true or false by way of its utility in accomplishing a certain task.